Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | BTK | Q06187 | 15/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 4/20 | 0.43 |
| ▸ | TEC | P42680 | 3/20 | 0.43 |
| ▸ | TXK | P42681 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 2/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | BLK | P51451 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31523792 | 1.00 | ITK (0.46) | ITKEGFRBTKFGFR2FGFR1 | |
| SCHEMBL31523992 | 0.90 | BTK (0.53) | ITKEGFRBTKFGFR2BMX | |
| SCHEMBL31523754 | 0.89 | ITK (0.44) | ITKEGFRBTKFGFR2FGFR1 | |
| SCHEMBL24459006 | 0.89 | ITK (0.44) | ITKEGFRBTKFGFR2FGFR1 | |
| SCHEMBL31523756 | 0.88 | RET (0.48) | ITKBTKFGFR2FGFR1FGFR3 | |
| SCHEMBL24458389 | 0.88 | RET (0.48) | ITKBTKFGFR2FGFR1FGFR3 | |
| SCHEMBL24459042 | 0.87 | BTK (0.50) | ITKEGFRBTKFGFR2FGFR1 | |
| SCHEMBL24458947 | 0.87 | BTK (0.48) | ITKEGFRBTKFGFR2FGFR1 | |
| SCHEMBL31523936 | 0.87 | BTK (0.48) | ITKEGFRBTKFGFR2FGFR1 | |
| SCHEMBL24459014 | 0.85 | ITK (0.46) | ITKEGFRBTKFGFR2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |