Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.42 |
| ▸ | BTK | Q06187 | 8/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31523780 | 1.00 | ITK (0.44) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL24458997 | 0.94 | ITK (0.45) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL31523960 | 0.94 | ITK (0.45) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL31523956 | 0.93 | ITK (0.44) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL24458621 | 0.93 | ITK (0.44) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL24458503 | 0.92 | RET (0.45) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL31523837 | 0.92 | RET (0.45) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL24458531 | 0.92 | RET (0.45) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL24458525 | 0.91 | RET (0.46) | ITKRETKIF5BFGFR1FGFR4 | |
| SCHEMBL31523759 | 0.91 | RET (0.46) | ITKRETKIF5BFGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |