Sugi Predict

Sugi Predict / Compounds / SCHEMBL24459064

SCHEMBL24459064

SCHEMBL24459064

Cc1cccc(Oc2ccc(-c3c(C#C[C@@H]4[C@H]5CN(C(=O)/C=C/CN6CCC(F)C6)C[C@@H]45)n(C)c4ncnc(N)c34)cc2)n1

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ FGFR2 P21802 12/20 0.46
▸ FGFR1 P11362 2/20 0.41
▸ FGFR4 P22455 2/20 0.41
▸ FGFR3 P22607 2/20 0.41
▸ BTK Q06187 7/20 0.40
▸ EGFR P00533 5/20 0.40
▸ LCK P06239 3/20 0.40
▸ ITK Q08881 3/20 0.40
▸ JAK3 P52333 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31524081 1.00 FGFR2 (0.46) FGFR2FGFR1FGFR4FGFR3BTK
SCHEMBL24458644 0.91 FGFR2 (0.49) FGFR2FGFR1FGFR4FGFR3BTK
SCHEMBL31523853 0.91 FGFR2 (0.49) FGFR2FGFR1FGFR4FGFR3BTK
SCHEMBL31523945 0.91 FGFR2 (0.46) FGFR2FGFR1FGFR4FGFR3ITK
SCHEMBL24458440 0.91 FGFR2 (0.46) FGFR2FGFR1FGFR4FGFR3ITK
SCHEMBL24458438 0.90 FGFR2 (0.47) FGFR2FGFR1FGFR4FGFR3
SCHEMBL31524019 0.90 FGFR2 (0.47) FGFR2FGFR1FGFR4FGFR3
SCHEMBL24458739 0.90 FGFR2 (0.47) FGFR2FGFR1FGFR4FGFR3BTK
SCHEMBL31523986 0.90 FGFR2 (0.47) FGFR2FGFR1FGFR4FGFR3BTK
SCHEMBL24458380 0.89 FGFR2 (0.48) FGFR2FGFR1FGFR4FGFR3BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022109551-A1 SRC INHIBITORS AND USES THEREOF RELAY THERAPEUTICS, INC. (US) 2022-05-27 — — WO disclosed
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