SCHEMBL24459090

C=CC(=O)N1C[C@@H]2[C@@H](C#Cc3c(-c4ccc(Oc5cccc(C)n5)c(OC)c4)c4c(N)ncnc4n3CCCS(C)(=O)=O)[C@@H]2C1

nearest known ligand 0.43

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	FGFR1	P11362	11/20	0.43

▸	FGFR2	P21802	6/20	0.43

▸	FGFR3	P22607	5/20	0.43

▸	ITK	Q08881	2/20	0.41

▸	FGFR4	P22455	8/20	0.40

▸	BTK	Q06187	5/20	0.38

▸	KDR	P35968	2/20	0.37

▸	EGFR	P00533	1/20	0.36

▸	ERBB2	P04626	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL31523999	1.00	FGFR1 (0.43)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL24459045	0.93	FGFR1 (0.44)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL31523996	0.93	FGFR1 (0.44)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL31523844	0.93	ITK (0.43)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL24458995	0.93	ITK (0.43)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL31523934	0.92	FGFR1 (0.43)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL24459006	0.89	ITK (0.44)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL31523754	0.89	ITK (0.44)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL24459055	0.89	FGFR1 (0.42)	FGFR1FGFR2FGFR3ITKFGFR4
SCHEMBL31523805	0.89	FGFR1 (0.42)	FGFR1FGFR2FGFR3ITKFGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022109551-A1	SRC INHIBITORS AND USES THEREOF	RELAY THERAPEUTICS, INC. (US)	2022-05-27	—	—	WO	disclosed