Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19781806 | 0.84 | GRK5 (0.48) | GRK5PIK3CDPIK3R1LRRK2KCNH2 | |
| SCHEMBL26815111 | 0.72 | PRKCI (0.50) | CYP19A1FAAHHSD11B1PIK3CB | |
| SCHEMBL16331389 | 0.66 | PIK3CD (0.70) | GRK5PIK3CDPIK3R1 | |
| SCHEMBL8025727 | 0.66 | PRKCI (0.49) | LRRK2CLK4FAAHHSD11B1 | |
| SCHEMBL16331368 | 0.65 | GRK5 (1.00) | GRK5PIK3CDPIK3R1CLK4 | |
| SCHEMBL30027129 | 0.65 | GRK5 (0.55) | GRK5PIK3CDPIK3R1LRRK2CLK4 | |
| SCHEMBL14518822 | 0.64 | CYP2A6 (0.46) | CYP19A1FAAHMTORPIK3CB | |
| SCHEMBL16331184 | 0.64 | FYN (0.67) | GRK5PIK3CDPIK3R1 | |
| SCHEMBL19662764 | 0.64 | LRRK2 (0.70) | PIK3CDLRRK2FAAHHSD11B1PIK3CA | |
| SCHEMBL19781539 | 0.63 | CLK1 (0.47) | KCNH2PIK3CAMTORFLT3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022108849-A1 | HETEROCYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ARISAN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |