Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.67 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14826052 | 0.87 | DYRK1A (0.85) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL18584820 | 0.80 | DYRK1A (1.00) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL1576521 | 0.80 | DYRK1A (0.73) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL14320570 | 0.79 | DYRK1A (0.71) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL31381049 | 0.79 | DYRK1A (0.71) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL8828283 | 0.78 | DYRK1A (0.65) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL20641173 | 0.77 | DYRK1A (0.63) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL1349106 | 0.75 | DYRK1A (0.70) | DYRK1ARETMEN1CYP1A2KMT2A | |
| Cyanide SCHEMBL22130062 | 0.74 | DYRK1A (0.55) | DYRK1ARETMEN1CYP1A2KMT2A | |
| SCHEMBL15743300 | 0.74 | DYRK1A (0.69) | DYRK1ARETMEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022108849-A1 | HETEROCYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ARISAN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |