Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 9/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24460447 | 0.85 | RYR2 (0.51) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL29563522 | 0.85 | RYR2 (0.51) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL29563568 | 0.85 | RYR2 (0.51) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL24460459 | 0.85 | RYR2 (0.51) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL29563477 | 0.85 | RYR2 (0.51) | RYR2HRH4CA2CHKAKCNH2 | |
| SCHEMBL24460437 | 0.85 | RYR2 (0.51) | RYR2HRH4CA2CHKAKCNH2 | |
| Hydrochloric Acid SCHEMBL29563975 | 0.84 | RYR2 (0.50) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL24460348 | 0.82 | RYR2 (0.48) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL29563519 | 0.82 | RYR2 (0.48) | RYR2CA2CHKAKCNH2SIGMAR1 | |
| SCHEMBL7557374 | 0.81 | NOTUM (0.47) | RYR2ALDH1A1MCL1NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022108945-A1 | AGENTS FOR TREATING DISORDERS INVOLVING RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2022-05-27 | — | — | WO | disclosed |