Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19781160 | 0.88 | FLT3 (0.43) | MAP4K4CYP1A2ACACBACACAWDR5 | |
| SCHEMBL24460364 | 0.87 | MAP4K4 (0.40) | MAP4K4CYP1A2ACACBACACAWDR5 | |
| SCHEMBL24460388 | 0.85 | PDE10A (0.42) | TGFBR1FLT3PIK3CAMTOR | |
| SCHEMBL24460211 | 0.82 | KDR (0.40) | MAP4K4CYP1A2ACACBACACABMPR1B | |
| SCHEMBL24460309 | 0.82 | ALOX5AP (0.39) | MAPTTGFBR1FFAR4 | |
| SCHEMBL24460242 | 0.81 | PIK3CA (0.39) | MAP4K4CYP1A2ACACBACACAWDR5 | |
| SCHEMBL24460254 | 0.81 | RIPK2 (0.41) | MAP4K4CYP1A2ACACBACACAFLT3 | |
| SCHEMBL22071837 | 0.81 | RIPK2 (0.41) | MAP4K4CYP1A2ACACBACACACLK1 | |
| SCHEMBL24460264 | 0.81 | RIPK2 (0.41) | MAP4K4CYP1A2ACACBACACAFLT3 | |
| SCHEMBL24460399 | 0.81 | CLK1 (0.47) | MAP4K4CYP1A2WDR5TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022108849-A1 | HETEROCYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ARISAN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |