Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.69 |
| ▸ | ITGB6 | P18564 | 16/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.69 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.69 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.69 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.69 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.69 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446101 | 1.00 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL278118 | 0.91 | ITGAV (0.62) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL278117 | 0.91 | ITGAV (0.62) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL21776328 | 0.86 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL2440964 | 0.86 | ITGAV (0.52) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL275079 | 0.86 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL5584347 | 0.86 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL21713112 | 0.84 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL21744208 | 0.84 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 | |
| SCHEMBL21744205 | 0.84 | ITGAV (0.69) | ITGAVITGB6ITGB3ITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747222-B1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | GALAPAGOS NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| EP-2368891-B1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | GALAPAGOS NV (BE) | 2012-09-19 | — | — | EP | disclosed |
| EP-2368891-A1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | Galapagos SAS (FR) | 2011-09-28 | — | — | EP | disclosed |