Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.68 |
| ▸ | TXK | P42681 | 13/20 | 0.68 |
| ▸ | JAK3 | P52333 | 13/20 | 0.68 |
| ▸ | ITK | Q08881 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24467347 | 0.86 | JAK3 (0.68) | BTKTXKJAK3ITK | |
| SCHEMBL20161863 | 0.81 | BTK (1.00) | BTKTXKJAK3ITK | |
| SCHEMBL24467248 | 0.80 | ITK (0.70) | BTKTXKJAK3ITK | |
| SCHEMBL24467190 | 0.79 | BTK (0.71) | BTKTXKJAK3ITK | |
| SCHEMBL24467251 | 0.78 | JAK3 (0.46) | BTKTXKJAK3ITK | |
| SCHEMBL24467153 | 0.76 | JAK3 (0.48) | BTKTXKJAK3ITK | |
| SCHEMBL20161434 | 0.75 | TXK (1.00) | BTKTXKJAK3ITK | |
| SCHEMBL20161680 | 0.75 | TXK (1.00) | BTKTXKJAK3ITK | |
| SCHEMBL24146471 | 0.74 | ITK (0.56) | BTKTXKJAK3ITK | |
| SCHEMBL24467238 | 0.74 | JAK3 (0.66) | BTKTXKJAK3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3534899-B1 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS INC (US) | 2022-06-01 | — | — | EP | disclosed |