Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24468954 | 1.00 | PRMT5 (0.44) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL29106192 | 1.00 | PRMT5 (0.44) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL29685876 | 1.00 | PRMT5 (0.44) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL29685609 | 0.95 | PRMT5 (0.43) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL24468738 | 0.95 | PRMT5 (0.43) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL27180529 | 0.95 | PRMT5 (0.43) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| Trifluoroacetic Acid SCHEMBL29685754 | 0.93 | PRMT5 (0.42) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| Trifluoroacetic Acid SCHEMBL27181276 | 0.93 | PRMT5 (0.42) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL24468735 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8CXCR3SCN9A | |
| SCHEMBL29685620 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8CXCR3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | claimed |
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |