Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 5/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24468497 | 0.84 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL29650821 | 0.84 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL29685674 | 0.83 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL29686007 | 0.81 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL24468588 | 0.75 | KDM4C (0.46) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL29875781 | 0.75 | KDM4C (0.46) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL24468498 | 0.75 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL29651065 | 0.75 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL29685763 | 0.75 | KDM4C (0.46) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL29650989 | 0.74 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |