Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29685468 | 1.00 | PRMT5 (0.49) | PRMT5WDR77TRPM8ITGB3ITGAV | |
| SCHEMBL29685483 | 1.00 | PRMT5 (0.49) | PRMT5WDR77TRPM8ITGB3ITGAV | |
| SCHEMBL27181245 | 0.91 | PRMT5 (0.48) | PRMT5WDR77TRPM8SCN9AMCHR1 | |
| SCHEMBL29685302 | 0.90 | PRMT5 (0.48) | PRMT5WDR77TRPM8SCN9AMCHR1 | |
| SCHEMBL24468560 | 0.90 | PRMT5 (0.48) | PRMT5WDR77TRPM8SCN9AMCHR1 | |
| SCHEMBL27472839 | 0.90 | PRMT5 (0.48) | PRMT5WDR77TRPM8ITGB3ITGAV | |
| SCHEMBL30971468 | 0.90 | PRMT5 (0.48) | PRMT5WDR77TRPM8ITGB3ITGAV | |
| SCHEMBL24468619 | 0.90 | PRMT5 (0.47) | PRMT5WDR77TRPM8SCN9AMCHR1 | |
| SCHEMBL29685406 | 0.90 | PRMT5 (0.47) | PRMT5WDR77TRPM8SCN9AMCHR1 | |
| SCHEMBL24468123 | 0.89 | PRMT5 (0.54) | PRMT5WDR77TRPM8SCN9AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | claimed |
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |