Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27181694 | 0.95 | PRMT5 (0.47) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL27181316 | 0.95 | PRMT5 (0.46) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL29685112 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL30842028 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL24468357 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL24468211 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL29106258 | 0.92 | PRMT5 (0.46) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL29106333 | 0.91 | PRMT5 (0.47) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL29106134 | 0.91 | PRMT5 (0.47) | PRMT5WDR77TRPM8PPARGPPARD | |
| SCHEMBL24468828 | 0.90 | PRMT5 (0.45) | PRMT5WDR77TRPM8PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |