Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 9/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 7/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317131 | 1.00 | KDM1A (0.49) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL13354763 | 0.87 | PDPK1 (0.45) | KDM1APDPK1AURKBTGFBR1AURKA | |
| SCHEMBL1317339 | 0.87 | PDPK1 (0.50) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL3126962 | 0.84 | PDPK1 (0.51) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL16966440 | 0.84 | PDPK1 (0.51) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL1318419 | 0.84 | PDPK1 (0.51) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL1317457 | 0.82 | PDPK1 (0.42) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL1318388 | 0.82 | PDPK1 (0.65) | KDM1APDPK1AURKBTGFBR1AURKA | |
| SCHEMBL1320552 | 0.82 | PDPK1 (0.42) | KDM1AMTORPDPK1AURKBTGFBR1 | |
| SCHEMBL1318453 | 0.82 | PDPK1 (0.42) | KDM1AMTORPDPK1AURKBTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |