Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448030 | 1.00 | CDK4 (0.39) | CDK4CCND1HCRTR2HCRTR1MEN1 | |
| SCHEMBL3416131 | 0.94 | CDK4 (0.41) | CDK4CCND1HCRTR2HCRTR1MEN1 | |
| SCHEMBL2926957 | 0.94 | CDK4 (0.41) | CDK4CCND1HCRTR2HCRTR1MEN1 | |
| SCHEMBL3414065 | 0.94 | CDK4 (0.41) | CDK4CCND1HCRTR2HCRTR1MEN1 | |
| SCHEMBL2450566 | 0.90 | TSHR (0.41) | HCRTR2HCRTR1MEN1ALDH1A1KMT2A | |
| SCHEMBL2450565 | 0.90 | TSHR (0.41) | HCRTR2HCRTR1MEN1ALDH1A1KMT2A | |
| SCHEMBL2450549 | 0.89 | HCRTR2 (0.41) | HCRTR2HCRTR1ALDH1A1 | |
| SCHEMBL2450550 | 0.89 | HCRTR2 (0.41) | HCRTR2HCRTR1ALDH1A1 | |
| SCHEMBL2446746 | 0.87 | HCRTR1 (0.40) | CDK4CCND1HCRTR2HCRTR1MEN1 | |
| SCHEMBL2446743 | 0.87 | HCRTR1 (0.40) | CDK4CCND1HCRTR2HCRTR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164847-B1 | 3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-09-14 | — | — | EP | claimed |