Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.78 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184530 | 0.88 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL183968 | 0.78 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL196373 | 0.78 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL184312 | 0.77 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL2325643 | 0.76 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL184520 | 0.75 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL184494 | 0.75 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL184320 | 0.75 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL184156 | 0.74 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL184683 | 0.74 | PDE4B (0.83) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148876-B1 | PYRAZOLONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2011-09-28 | — | — | EP | disclosed |