Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 20/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | PRKCG | P05129 | 1/20 | 0.68 |
| ▸ | PRKCB | P05771 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 1/20 | 0.68 |
| ▸ | PRKCA | P17252 | 1/20 | 0.68 |
| ▸ | PRKCH | P24723 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | PRKCI | P41743 | 1/20 | 0.68 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.68 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.68 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.68 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2442248 | 1.00 | EGFR (0.79) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2442406 | 0.92 | EGFR (0.81) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2444028 | 0.88 | EGFR (1.00) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2444943 | 0.87 | EGFR (0.81) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2443036 | 0.87 | EGFR (1.00) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2443456 | 0.87 | EGFR (0.79) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL6359623 | 0.86 | EGFR (0.78) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2446292 | 0.86 | EGFR (0.80) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL2448473 | 0.85 | EGFR (0.69) | EGFRERBB2PRKD3PRKCGPRKCB | |
| SCHEMBL6355962 | 0.84 | EGFR (0.77) | EGFRERBB2PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446401-B1 | C5-modified indazolylpyrrolotriazines | BRISTOL MYERS SQUIBB CO (US) | 2011-09-14 | — | — | EP | disclosed |
| US-6908916-B2 | C-5 modified indazolylpyrrolotriazines | BRISTOL MYERS SQUIBB COMPANY (US) | 2005-06-21 | — | — | US | disclosed |