Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242635 | 1.00 | CYP3A4 (0.75) | CYP3A4PSIP1NR1I2MAPK14 | |
| SCHEMBL15182557 | 0.94 | CYP3A4 (0.66) | CYP3A4PSIP1MAPK14 | |
| SCHEMBL15093556 | 0.93 | CYP3A4 (0.65) | CYP3A4PSIP1MAPK14 | |
| SCHEMBL15102828 | 0.93 | CYP3A4 (0.65) | CYP3A4PSIP1MAPK14 | |
| SCHEMBL15093597 | 0.93 | CYP3A4 (0.65) | CYP3A4PSIP1MAPK14 | |
| SCHEMBL15102825 | 0.93 | CYP3A4 (0.65) | CYP3A4PSIP1MAPK14 | |
| SCHEMBL244907 | 0.92 | CYP3A4 (0.75) | CYP3A4PSIP1NR1I2MAPK14 | |
| SCHEMBL15102829 | 0.92 | CYP3A4 (0.73) | CYP3A4PSIP1NR1I2MAPK14 | |
| SCHEMBL15102796 | 0.92 | CYP3A4 (0.73) | CYP3A4PSIP1NR1I2MAPK14 | |
| SCHEMBL15182548 | 0.92 | CYP3A4 (0.64) | CYP3A4PSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |
| US-9296758-B2 | 2-quinolinyl-acetic acid derivatives as HIV antiviral compounds | GILEAD SCIENCES, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| EP-2588455-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003498-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |