Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | CDK4 | P11802 | 12/20 | 0.48 |
| ▸ | CCND1 | P24385 | 10/20 | 0.48 |
| ▸ | CDK2 | P24941 | 7/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.47 |
| ▸ | CCND3 | P30281 | 5/20 | 0.47 |
| ▸ | CCND2 | P30279 | 4/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975110 | 0.85 | FGFR4 (0.61) | FGFR4FGFR1BRD4FGFR2FGFR3 | |
| SCHEMBL5768493 | 0.80 | FGFR4 (0.57) | FGFR4FGFR1FLT3FGFR2FGFR3 | |
| SCHEMBL3967389 | 0.79 | LCK (0.54) | FGFR4FGFR1CDK4CCND1FLT3 | |
| SCHEMBL22532363 | 0.75 | FGFR4 (0.64) | FGFR4FGFR1BRD4FGFR2FGFR3 | |
| SCHEMBL22532594 | 0.75 | FGFR4 (0.71) | FGFR4FGFR1FLT3FGFR2FGFR3 | |
| SCHEMBL3979713 | 0.73 | FGFR4 (0.52) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL3970864 | 0.72 | FGFR1 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL3974703 | 0.72 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16134003 | 0.72 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL3971040 | 0.72 | FGFR4 (0.64) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220175722-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175722-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | FGFR2, FGF2, FGFR1 | FGFR4 6/4885FGFR1 3/4885BRD4 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.