Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.48 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 6/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.31 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | GCKR | Q14397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496015 | 1.00 | BRD4 (0.48) | BRD4TEAD1YAP1SYKFLT3 | |
| SCHEMBL29648372 | 0.84 | TEAD1 (0.60) | BRD4TEAD1YAP1SYKITK | |
| SCHEMBL20779716 | 0.84 | TEAD1 (0.60) | BRD4TEAD1YAP1SYKITK | |
| SCHEMBL20779718 | 0.84 | TEAD1 (0.60) | BRD4TEAD1YAP1SYKITK | |
| SCHEMBL22635634 | 0.84 | TEAD1 (0.60) | BRD4TEAD1YAP1SYKITK | |
| SCHEMBL24496021 | 0.81 | FLT3 (0.39) | FLT3TYRO3MERTKGAS6IRAK4 | |
| SCHEMBL24880087 | 0.80 | BRD4 (0.41) | BRD4SYKJAK2JAK3 | |
| SCHEMBL24496378 | 0.78 | FLT3 (0.40) | TEAD1YAP1SYKFLT3TYRO3 | |
| SCHEMBL24501949 | 0.78 | TEAD1 (0.49) | BRD4TEAD1YAP1SYKKAT6A | |
| SCHEMBL30876295 | 0.77 | TEAD1 (0.42) | BRD4TEAD1YAP1SYKKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |