Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.59 |
| ▸ | YAP1 | P46937 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 10/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648384 | 1.00 | TEAD1 (0.59) | TEAD1YAP1TSHRL3MBTL1CYP19A1 | |
| SCHEMBL24496133 | 0.92 | TEAD1 (0.60) | TEAD1YAP1TSHRL3MBTL1CYP19A1 | |
| SCHEMBL24496265 | 0.90 | TEAD1 (0.58) | TEAD1YAP1TSHRL3MBTL1CYP19A1 | |
| SCHEMBL22718245 | 0.90 | TEAD1 (0.74) | TEAD1YAP1TSHRL3MBTL1CYP19A1 | |
| SCHEMBL24496334 | 0.88 | TEAD1 (0.56) | TEAD1YAP1TSHRL3MBTL1CYP19A1 | |
| SCHEMBL29648336 | 0.88 | TEAD1 (0.56) | TEAD1YAP1TSHRCYP19A1KMT2A | |
| SCHEMBL24496011 | 0.88 | TEAD1 (0.56) | TEAD1YAP1TSHRCYP19A1KMT2A | |
| SCHEMBL24496156 | 0.88 | TEAD1 (0.56) | TEAD1YAP1TSHRL3MBTL1CYP19A1 | |
| SCHEMBL24496033 | 0.88 | TEAD1 (0.59) | TEAD1YAP1TSHRL3MBTL1PTGS2 | |
| SCHEMBL29648345 | 0.88 | TEAD1 (0.59) | TEAD1YAP1TSHRL3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |