Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648409 | 1.00 | TEAD1 (0.43) | TEAD1YAP1LRRK2GPR52PRKAB2 | |
| SCHEMBL29648356 | 0.92 | TEAD1 (0.41) | TEAD1YAP1LRRK2GPR52PRKAB2 | |
| SCHEMBL24501061 | 0.92 | TEAD1 (0.41) | TEAD1YAP1LRRK2GPR52PRKAB2 | |
| SCHEMBL24501749 | 0.91 | TEAD1 (0.39) | TEAD1YAP1LRRK2GPR52PRKAB2 | |
| SCHEMBL24496100 | 0.86 | TLR2 (0.51) | TEAD1YAP1JAK1TYK2KCNH2 | |
| SCHEMBL24496101 | 0.84 | TEAD1 (0.49) | TEAD1YAP1JAK1TYK2KCNH2 | |
| SCHEMBL24501691 | 0.84 | TEAD1 (0.47) | TEAD1YAP1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL24496155 | 0.83 | MAPT (0.45) | TEAD1YAP1LRRK2GPR52MRGPRX4 | |
| SCHEMBL29648385 | 0.83 | MAPT (0.45) | TEAD1YAP1LRRK2GPR52MRGPRX4 | |
| SCHEMBL29704148 | 0.80 | TEAD1 (0.46) | TEAD1YAP1JAK1TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |