Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648361 | 1.00 | TEAD1 (0.55) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL29438907 | 0.96 | TEAD1 (0.56) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL22718179 | 0.96 | TEAD1 (0.56) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL29648306 | 0.81 | TEAD1 (0.58) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL22718188 | 0.81 | TEAD1 (0.66) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL29438838 | 0.81 | TEAD1 (0.66) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL29648310 | 0.81 | TEAD1 (0.58) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL24496007 | 0.81 | TEAD1 (0.58) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL24496009 | 0.81 | TEAD1 (0.58) | TEAD1YAP1GABRA1GABRG2GABRB3 | |
| SCHEMBL22843438 | 0.80 | TEAD1 (0.40) | TEAD1YAP1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |