Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | PGR | P06401 | 8/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29596832 | 1.00 | MAPK14 (0.41) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24496419 | 0.98 | MAPK14 (0.40) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29596945 | 0.98 | MAPK14 (0.40) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29597305 | 0.97 | MAPK14 (0.41) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24496411 | 0.97 | MAPK14 (0.41) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24496560 | 0.95 | MAPK14 (0.36) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29596629 | 0.95 | MAPK14 (0.36) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23778395 | 0.89 | MEN1 (0.36) | MAPK14PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24496403 | 0.87 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL24496551 | 0.82 | MAPK14 (0.34) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4257584-A1 | 2,3-DIHYDRO-1H-PYRROLO[3,2-B]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022116995-A1 | 2,3-DIHYDRO-1H-PYRROLO[3,2-B]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2022-06-09 | — | — | WO | disclosed |