Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908734 | 1.00 | KMT2A (0.63) | KMT2AMEN1MAPK1KDM4EHIF1A | |
| SCHEMBL18908735 | 0.92 | KMT2A (0.73) | KMT2AMEN1MAPK1KDM4EMTNR1A | |
| SCHEMBL10447931 | 0.92 | KMT2A (0.73) | KMT2AMEN1MAPK1KDM4EMTNR1A | |
| SCHEMBL18908674 | 0.92 | KMT2A (0.73) | KMT2AMEN1MAPK1KDM4EMTNR1A | |
| SCHEMBL12387741 | 0.90 | KMT2A (0.69) | KMT2AMEN1MAPK1MTNR1ATSHR | |
| SCHEMBL5155263 | 0.85 | MEN1 (0.56) | KMT2AMEN1MAPK1KDM4EHIF1A | |
| SCHEMBL19309079 | 0.85 | MEN1 (0.56) | KMT2AMEN1MAPK1KDM4EHIF1A | |
| SCHEMBL23568253 | 0.85 | KMT2A (0.59) | KMT2AMEN1MAPK1TSHRCYP2D6 | |
| SCHEMBL25128239 | 0.85 | KMT2A (0.59) | KMT2AMEN1MAPK1MTNR1ATSHR | |
| SCHEMBL21106192 | 0.85 | KMT2A (0.59) | KMT2AMEN1MAPK1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |