Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.64 |
| ▸ | WIZ | O95785 | 5/20 | 0.56 |
| ▸ | IKZF2 | Q9UKS7 | 4/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29439985 | 1.00 | CRBN (0.64) | CRBNWIZIKZF2ITGB3ITGA2B | |
| SCHEMBL29648433 | 0.99 | CRBN (0.63) | CRBNWIZIKZF2ITGB3ITGA2B | |
| SCHEMBL22360830 | 0.99 | CRBN (0.63) | CRBNWIZIKZF2ITGB3ITGA2B | |
| SCHEMBL24500580 | 0.99 | CRBN (0.63) | CRBNWIZIKZF2ITGB3ITGA2B | |
| SCHEMBL24501670 | 0.97 | CRBN (0.65) | CRBNWIZIKZF2CSNK1A1 | |
| SCHEMBL31134607 | 0.94 | CRBN (0.67) | CRBNWIZIKZF2CSNK1A1 | |
| SCHEMBL24501550 | 0.90 | CRBN (0.62) | CRBNWIZIKZF2 | |
| SCHEMBL29648417 | 0.90 | CRBN (0.62) | CRBNWIZIKZF2 | |
| SCHEMBL29648275 | 0.90 | CRBN (0.62) | CRBNWIZIKZF2 | |
| SCHEMBL24817722 | 0.90 | CRBN (0.61) | CRBNWIZIKZF2CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |