Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 16/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29694670 | 1.00 | POLQ (0.45) | POLQKDM4EDHFRMRGPRX4 | |
| SCHEMBL30016043 | 0.89 | POLQ (0.45) | POLQKDM4EDHFR | |
| SCHEMBL24770262 | 0.89 | POLQ (0.45) | POLQKDM4EDHFR | |
| SCHEMBL24770258 | 0.88 | POLQ (0.45) | POLQKDM4EDHFRMRGPRX4 | |
| SCHEMBL24500340 | 0.82 | POLQ (0.59) | POLQDHFR | |
| SCHEMBL24501363 | 0.82 | POLQ (0.47) | POLQKDM4EDHFR | |
| SCHEMBL24769346 | 0.80 | PDCD1 (0.41) | POLQ | |
| SCHEMBL24769644 | 0.79 | POLQ (0.63) | POLQKDM4EDHFRMRGPRX4 | |
| SCHEMBL31032138 | 0.79 | POLQ (0.63) | POLQKDM4EDHFRMRGPRX4 | |
| SCHEMBL30858984 | 0.79 | POLQ (0.51) | POLQDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |