Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.40 |
| ▸ | BRAF | P15056 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496248 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29648342 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL30828322 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL24496246 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29648287 | 1.00 | TEAD1 (0.55) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL24496009 | 0.91 | TEAD1 (0.58) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29648306 | 0.91 | TEAD1 (0.58) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29648310 | 0.85 | TEAD1 (0.58) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL24496007 | 0.85 | TEAD1 (0.58) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL30828298 | 0.83 | TEAD1 (0.57) | TEAD1YAP1TNNI3KBRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |