Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 13/20 | 0.87 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.87 |
| ▸ | PRKCG | P05129 | 4/20 | 0.87 |
| ▸ | PRKCB | P05771 | 4/20 | 0.87 |
| ▸ | LCK | P06239 | 4/20 | 0.87 |
| ▸ | PRKCA | P17252 | 4/20 | 0.87 |
| ▸ | PRKCH | P24723 | 4/20 | 0.87 |
| ▸ | PRKCI | P41743 | 4/20 | 0.87 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.87 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.87 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.87 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.87 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.87 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21107542 | 0.94 | ZAP70 (0.84) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6945045 | 0.93 | ZAP70 (1.00) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6945041 | 0.93 | ZAP70 (1.00) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL21107541 | 0.90 | ZAP70 (0.91) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL21106674 | 0.88 | ZAP70 (0.87) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL22909026 | 0.88 | ZAP70 (0.90) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6951384 | 0.87 | ZAP70 (0.88) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL7260761 | 0.85 | ZAP70 (0.84) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6957175 | 0.85 | ZAP70 (0.84) | ZAP70PRKD3PRKCGPRKCBLCK | |
| SCHEMBL6957285 | 0.84 | ZAP70 (1.00) | ZAP70PRKD3PRKCGPRKCBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230398223-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-20230398223-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-11723980-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-08-15 | — | — | US | disclosed |
| US-11723980-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-08-15 | — | — | US | disclosed |
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | ZAP70 452/4885PRKD3 933/4885PRKCG 1287/4885 |
| US-11723980-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ZAP70 452/4885PRKD3 933/4885PRKCG 1287/4885 |
| US-20230398223-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | ZAP70 452/4885PRKD3 933/4885PRKCG 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.