⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089200 | 0.83 | CCR1 (0.32) | — | |
| SCHEMBL20985967 | 0.81 | KDM4E (0.34) | — | |
| SCHEMBL23089765 | 0.80 | — | — | |
| SCHEMBL24508618 | 0.80 | EGFR (0.33) | — | |
| SCHEMBL23104252 | 0.73 | — | — | |
| SCHEMBL24780130 | 0.68 | DYRK1B (0.34) | — | |
| SCHEMBL25045595 | 0.67 | KDM4E (0.36) | — | |
| SCHEMBL20049573 | 0.67 | MAPT (0.33) | — | |
| SCHEMBL23104791 | 0.66 | IKBKB (0.33) | — | |
| SCHEMBL20919583 | 0.66 | CDK4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259128-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| CN-116669722-A | Interleukin-1 receptor-related kinase (IRAK) degradants and uses thereof | 凯麦拉医疗公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |