Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25468987 | 0.90 | PIK3CD (0.37) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL23842181 | 0.85 | PIK3CD (0.42) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL22526354 | 0.85 | PIK3CD (0.42) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL23567976 | 0.85 | PIK3CD (0.42) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL24508769 | 0.84 | PIK3CD (0.39) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL23602418 | 0.82 | PIK3CD (0.38) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL25702277 | 0.82 | PIK3CD (0.38) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL23560022 | 0.82 | PIK3CD (0.38) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL23807050 | 0.82 | EPHX1 (0.41) | PIK3CDDRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL23806884 | 0.82 | EPHX1 (0.41) | PIK3CDDRD4KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147465-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |