Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25557251 | 1.00 | EPHX1 (0.46) | EPHX1HRH4HRH3PAOXKISS1R | |
| SCHEMBL25832099 | 1.00 | EPHX1 (0.46) | EPHX1HRH4HRH3PAOXKISS1R | |
| SCHEMBL3348281 | 0.92 | HRH4 (0.38) | EPHX1HRH4HRH3PAOXKISS1R | |
| SCHEMBL5298781 | 0.89 | HRH4 (0.48) | EPHX1HRH4HRH3GRIN1GRIN2A | |
| SCHEMBL24379824 | 0.89 | HRH4 (0.48) | EPHX1HRH4HRH3GRIN1GRIN2A | |
| SCHEMBL2483497 | 0.89 | HRH4 (0.48) | EPHX1HRH4HRH3GRIN1GRIN2A | |
| SCHEMBL9624660 | 0.87 | HRH4 (0.47) | EPHX1HRH4HRH3GRIN1GRIN2A | |
| SCHEMBL21107061 | 0.82 | HTR1B (0.34) | EPHX1HRH4HRH3PAOXKISS1R | |
| SCHEMBL3318903 | 0.81 | — | — | |
| SCHEMBL2478778 | 0.81 | HRH4 (0.42) | EPHX1HRH4HRH3GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |