Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24779960 | 0.94 | NPC1 (0.44) | NPC1LMNAGBA1 | |
| SCHEMBL17916210 | 0.86 | NPC1 (0.39) | NPC1 | |
| SCHEMBL1298498 | 0.86 | NPC1 (0.41) | NPC1LMNA | |
| SCHEMBL9251176 | 0.82 | NPC1 (0.43) | NPC1 | |
| SCHEMBL22791025 | 0.80 | GBA1 (0.38) | NPC1GBA1 | |
| SCHEMBL13179275 | 0.80 | — | — | |
| SCHEMBL9251921 | 0.80 | NPC1 (0.47) | NPC1 | |
| SCHEMBL9128054 | 0.80 | NPC1 (0.47) | NPC1 | |
| SCHEMBL13141317 | 0.79 | MEN1 (0.44) | LMNA | |
| SCHEMBL22794630 | 0.79 | HRH3 (0.37) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |