Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 4/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | BACE1 | P56817 | 4/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24511682 | 1.00 | FUCA1 (0.54) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL24511693 | 1.00 | FUCA1 (0.54) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL24511683 | 1.00 | FUCA1 (0.54) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL24511691 | 1.00 | FUCA1 (0.54) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL1845568 | 0.80 | GRIN2B (0.54) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL25176271 | 0.80 | TSHR (0.58) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| Methyl Alcohol SCHEMBL27513196 | 0.79 | GRIN2B (0.67) | GRIN2BMEN1RAB9AKMT2AACHE | |
| SCHEMBL29809339 | 0.79 | FUCA1 (0.55) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL28716809 | 0.78 | GRIN2B (0.55) | FUCA1GRIN2BMEN1RAB9AKMT2A | |
| SCHEMBL663239 | 0.77 | GRIN2B (0.74) | GRIN2BMEN1RAB9AKMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022122876-A1 | N-(IMIDAZO[1,2-B]PYRIDAZIN-3-YL)-1-CYCLOHEXYL-2H-INDAZOLE-5-CARBOXAMIDE AND N-(PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-1-CYCLOHEXYL-2H-INDAZOLE-5-CARBOXAMIDE DERIVATIVES AS IRAK4 INHIBITORS FOR THE TREATMENT OF ASTHMA | ASTRAZENECA AB (SE) | 2022-06-16 | — | — | WO | disclosed |