SCHEMBL24512397

SCHEMBL24512397

CC(C)(C)[Si](C)(C)OC[C@H]1OC(n2cnc(N)nc2=O)C[C@@H]1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 2/20 0.67
ADRB1 P08588 1/20 0.67
POLB P06746 3/20 0.45
LMNA P02545 2/20 0.44
TP53 P04637 2/20 0.44
HTT P42858 2/20 0.44
GMNN O75496 1/20 0.44
ALDH1A1 P00352 1/20 0.44
NFKB1 P19838 1/20 0.44
THPO P40225 1/20 0.44
MTOR P42345 1/20 0.44
RAB9A P51151 1/20 0.44
BLM P54132 1/20 0.44
HBB P68871 1/20 0.44
PMP22 Q01453 1/20 0.44
NT5E P21589 1/20 0.42
TYMP P19971 1/20 0.41
PNP P00491 1/20 0.39
PDE4D Q08499 1/20 0.39
PDE3A Q14432 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20651314 1.00 DNMT1 (0.67) DNMT1ADRB1POLBLMNATP53
SCHEMBL23358428 1.00 DNMT1 (0.67) DNMT1ADRB1POLBLMNATP53
SCHEMBL23371822 1.00 DNMT1 (0.67) DNMT1ADRB1POLBLMNATP53
SCHEMBL5076376 0.89 DNMT1 (0.73) DNMT1ADRB1POLBLMNATP53
SCHEMBL20651604 0.88 DNMT1 (0.54) DNMT1ADRB1POLBLMNATP53
SCHEMBL23624606 0.87 DNMT1 (0.52) DNMT1ADRB1POLBLMNATP53
SCHEMBL19470027 0.86 DNMT1 (0.69) DNMT1ADRB1POLBLMNATP53
SCHEMBL16366026 0.86 DNMT1 (0.74) DNMT1ADRB1POLBLMNATP53
SCHEMBL10064225 0.86 DNMT1 (0.74) DNMT1ADRB1POLBLMNATP53
SCHEMBL19283452 0.85 DNMT1 (0.76) DNMT1ADRB1POLBLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022123501-A1 PROTECTED DEOXYDIDEHYDRO-NUCLEOSIDES VICTORIA LINK LIMITED (NZ) 2022-06-16 WO disclosed