Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.36 |
| ▸ | PRLHR | P49683 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450717 | 0.93 | CREBBP (0.41) | CREBBPBRD4GPR119PRLHRIMPDH2 | |
| SCHEMBL2445064 | 0.92 | CREBBP (0.42) | CREBBPBRD4GPR119PRLHRIMPDH2 | |
| SCHEMBL2444397 | 0.91 | BRD4 (0.36) | CREBBPBRD4IMPDH2PDE10AALDH1A1 | |
| SCHEMBL2447141 | 0.86 | CREBBP (0.41) | CREBBPBRD4GPR119PRLHRIMPDH2 | |
| SCHEMBL2450465 | 0.86 | PDE10A (0.37) | CREBBPBRD4IMPDH2PDE10AMTOR | |
| SCHEMBL2844520 | 0.85 | MAPT (0.42) | CREBBPBRD4GPR119PRLHRPDE10A | |
| SCHEMBL2446851 | 0.85 | CREBBP (0.42) | CREBBPBRD4PRLHRIMPDH2CYP3A4 | |
| SCHEMBL2450613 | 0.85 | CREBBP (0.51) | CREBBPBRD4PRLHRIMPDH2PDE10A | |
| SCHEMBL2450149 | 0.85 | CREBBP (0.43) | CREBBPBRD4GPR119PRLHRIMPDH2 | |
| SCHEMBL2452689 | 0.84 | CREBBP (0.38) | CREBBPBRD4PRLHRIMPDH2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |