SCHEMBL24514385 — predicted protein targets

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	PBRM1	Q86U86	18/20	0.42

▸	SMARCA2	P51531	16/20	0.40

▸	SMARCA4	P51532	16/20	0.40

▸	BRD4	O60885	1/20	0.39

▸	NR1I2	O75469	8/20	0.39

▸	NR1H2	P55055	4/20	0.37

▸	NR1H3	Q13133	3/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24514396	0.95	PBRM1 (0.43)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24513970	0.95	PBRM1 (0.41)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24514306	0.93	PBRM1 (0.43)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24514491	0.87	PBRM1 (0.38)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24514594	0.87	SMARCA2 (0.43)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24513946	0.86	PBRM1 (0.43)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24513968	0.86	PBRM1 (0.39)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24513942	0.85	PBRM1 (0.42)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24514278	0.85	PBRM1 (0.41)	PBRM1SMARCA2SMARCA4BRD4NR1I2
SCHEMBL24514279	0.85	PBRM1 (0.41)	PBRM1SMARCA2SMARCA4BRD4NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022125804-A1	SMARCA DEGRADERS AND USES THEREOF	KYMERA THERAPEUTICS, INC. (US)	2022-06-16	—	—	WO	disclosed