Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | WRN | Q14191 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24515203 | 1.00 | AR (0.45) | ARGRM4CDK8KDRBRAF | |
| SCHEMBL26613003 | 0.84 | AR (0.48) | ARGRM4CDK8KDRBRAF | |
| Bromide SCHEMBL30638609 | 0.82 | AR (0.47) | ARGRM4CDK8KDRBRAF | |
| SCHEMBL24516621 | 0.81 | AR (0.46) | ARGRM4CDK8KDRBRAF | |
| SCHEMBL24516620 | 0.81 | AR (0.46) | ARGRM4CDK8KDRBRAF | |
| SCHEMBL24515710 | 0.81 | AR (0.46) | ARGRM4KDRBRAF | |
| Hydrochloric Acid SCHEMBL26613248 | 0.81 | AR (0.45) | ARGRM4CDK8KDRBRAF | |
| SCHEMBL25642088 | 0.81 | RXFP1 (0.38) | — | |
| SCHEMBL24515838 | 0.80 | AR (0.44) | ARGRM4CDK8KDRBRAF | |
| SCHEMBL24515852 | 0.80 | AR (0.44) | ARGRM4CDK8KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022122773-A1 | 4-(2-FLUORO-4-METHOXY-5-3-(((1-METHYLCYCLOBUTYL)METHYL)CARBAMOYL)BICYCLO[2.2.1]HEPTAN-2-YL)CARBAMOYL)PHENOXY)-1-METHYLCYCLOHEXANE-1-CARBOXYLIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE | ASTRAZENECA AB (SE) | 2022-06-16 | — | — | WO | disclosed |