Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450149 | 0.90 | CREBBP (0.43) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2450616 | 0.89 | BRD4 (0.35) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2449611 | 0.88 | CREBBP (0.39) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2446856 | 0.88 | BRD4 (0.36) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2446711 | 0.87 | CREBBP (0.42) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2446851 | 0.87 | CREBBP (0.42) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2445064 | 0.87 | CREBBP (0.42) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2448754 | 0.87 | CREBBP (0.42) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2450465 | 0.86 | PDE10A (0.37) | CREBBPBRD4NPC1RAB9AKDM4E | |
| SCHEMBL2444397 | 0.86 | BRD4 (0.36) | CREBBPBRD4NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |