Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15552632 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL3L3MBTL1ALDH1A1CYP2A13 | |
| SCHEMBL12065889 | 0.83 | — | — | |
| SCHEMBL16878280 | 0.83 | — | — | |
| SCHEMBL13558432 | 0.83 | — | — | |
| SCHEMBL18207814 | 0.83 | SMN1; SMN2 (0.35) | SMN1; SMN2L3MBTL3L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL2115253 | 0.83 | — | — | |
| SCHEMBL16975571 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL3L3MBTL1ALDH1A1CYP2A13 | |
| SCHEMBL2358820 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL3L3MBTL1ALDH1A1HPGD | |
| SCHEMBL11024494 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL3L3MBTL1ALDH1A1HPGD | |
| SCHEMBL24221676 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL3L3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125849-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2022-06-16 | — | — | WO | disclosed |