Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602329 | 0.89 | S1PR1 (0.53) | S1PR1FFAR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2451751 | 0.84 | S1PR1 (0.42) | S1PR1FFAR1S1PR3PRMT5WDR77 | |
| SCHEMBL12785247 | 0.79 | S1PR1 (0.47) | S1PR1FFAR1S1PR3KCNH2 | |
| SCHEMBL1603344 | 0.79 | S1PR1 (0.47) | S1PR1FFAR1S1PR3KCNH2S1PR5 | |
| SCHEMBL1602525 | 0.77 | S1PR1 (0.46) | S1PR1FFAR1S1PR3PRMT5WDR77 | |
| SCHEMBL12706824 | 0.76 | S1PR1 (0.45) | S1PR1FFAR1S1PR3S1PR5 | |
| SCHEMBL1603020 | 0.73 | S1PR1 (0.52) | S1PR1FFAR1S1PR3PRMT5WDR77 | |
| SCHEMBL1601693 | 0.71 | S1PR1 (0.54) | S1PR1S1PR3S1PR5 | |
| SCHEMBL12319188 | 0.69 | S1PR1 (0.41) | S1PR1FFAR1S1PR3S1PR5 | |
| SCHEMBL1602801 | 0.69 | S1PR1 (0.47) | S1PR1FFAR1S1PR3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364976-B1 | S1P receptor modulating compounds and use thereof | EPIX PHARM INC (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-2364976-A1 | S1P receptor modulating compounds and use thereof | EPIX Pharmaceuticals, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |