Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 17/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 17/20 | 0.51 |
| ▸ | EIF4E | P06730 | 3/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24520085 | 0.91 | MKNK1 (0.54) | MKNK1MKNK2EIF4EMTOR | |
| SCHEMBL24520069 | 0.90 | MKNK1 (0.49) | MKNK1MKNK2EIF4EPIK3CA | |
| SCHEMBL24520049 | 0.85 | MKNK1 (0.53) | MKNK1MKNK2EIF4EMTOR | |
| SCHEMBL16620433 | 0.80 | MKNK1 (0.58) | MKNK1MKNK2EIF4E | |
| SCHEMBL16621227 | 0.80 | MKNK1 (0.57) | MKNK1MKNK2EIF4EPIK3CAPIK3CD | |
| SCHEMBL24520005 | 0.80 | PIK3CA (0.34) | PIK3CA | |
| SCHEMBL16626035 | 0.79 | MKNK1 (0.52) | MKNK1MKNK2EIF4E | |
| SCHEMBL16620579 | 0.79 | MKNK1 (0.52) | MKNK1MKNK2EIF4E | |
| SCHEMBL16620978 | 0.79 | MKNK1 (0.61) | MKNK1MKNK2EIF4E | |
| SCHEMBL16620317 | 0.76 | MKNK1 (0.65) | MKNK1MKNK2EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |