Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.55 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 5/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.52 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.52 |
| ▸ | NEK2 | P51955 | 2/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.52 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.52 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | KRAS | P01116 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20408840 | 0.92 | BRAF (0.56) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL16140157 | 0.85 | BRAF (0.70) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL24523141 | 0.85 | MAP2K4 (0.55) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL29796683 | 0.85 | CYP2C9 (0.75) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL20408837 | 0.85 | CYP2C9 (0.75) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL30866635 | 0.83 | CYP2C9 (0.69) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL21624550 | 0.83 | CYP2C9 (0.69) | CYP2C9MAP2K4BRAFRIPK2RAF1 | |
| SCHEMBL20324165 | 0.83 | CYP2C19 (0.60) | CYP2C9BRAFRIPK2RAF1KDR | |
| SCHEMBL20408771 | 0.83 | CYP2C19 (0.60) | CYP2C9BRAFRIPK2RAF1KDR | |
| SCHEMBL21592360 | 0.82 | BRAF (0.61) | CYP2C9BRAFRIPK2RAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571200-B1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2022-06-22 | — | — | EP | disclosed |