Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | TEK | Q02763 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 6/20 | 0.56 |
| ▸ | KIT | P10721 | 9/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 6/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24528562 | 0.88 | LCK (0.58) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL24528502 | 0.87 | CSF1R (0.51) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL29760179 | 0.86 | ABL1 (0.49) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL24528563 | 0.86 | ABL1 (0.49) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL22529514 | 0.85 | LCK (0.57) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL31405382 | 0.81 | TEK (0.43) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL11298448 | 0.80 | ABL1 (0.63) | LCKTEKKDRCSF1RKIT | |
| SCHEMBL24528528 | 0.80 | ATM (0.52) | KDRCSF1RKITABL1BCR | |
| SCHEMBL22833769 | 0.79 | CSF1R (0.68) | CSF1RKITABL1DDR1 | |
| SCHEMBL27974670 | 0.77 | KIT (0.76) | KITDDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129914-A1 | ALKYNE DERIVATIVES AS INHIBITORS OF C-ABL | BENEVOLENTAI BIO LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022129913-A1 | ALKYNE DERIVATIVES AS INHIBITORS OF C-ABL | BENEVOLENTAI BIO LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022129913-A1 | ALKYNE DERIVATIVES AS INHIBITORS OF C-ABL | BENEVOLENTAI BIO LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |