Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.79 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.79 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.79 |
| ▸ | CDK9 | P50750 | 13/20 | 0.77 |
| ▸ | CDK7 | P50613 | 4/20 | 0.77 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.77 |
| ▸ | CCNH | P51946 | 3/20 | 0.77 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.77 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.77 |
| ▸ | CDK1 | P06493 | 2/20 | 0.77 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.77 |
| ▸ | CIT | O14578 | 1/20 | 0.77 |
| ▸ | CASK | O14936 | 1/20 | 0.77 |
| ▸ | AURKA | O14965 | 1/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.77 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.77 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.77 |
| ▸ | ULK1 | O75385 | 1/20 | 0.77 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.77 |
| ▸ | PAK3 | O75914 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24528980 | 0.94 | CDK2 (0.79) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL4994410 | 0.94 | CDK2 (0.83) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24528966 | 0.93 | CDK2 (0.83) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24528861 | 0.93 | CDK2 (0.79) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24528860 | 0.90 | CDK2 (0.74) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL20905302 | 0.88 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL18613589 | 0.87 | CDK2 (0.84) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL24528750 | 0.87 | CDK2 (0.84) | CDK2CCNE2CCNE1CDK9CDK7 | |
| Bms-387032 SCHEMBL187401 | 0.87 | CDK2 (1.00) | CDK2CCNE2CCNE1CDK9CDK7 | |
| SCHEMBL27191482 | 0.87 | CDK2 (0.72) | CDK2CCNE2CCNE1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |