Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | CD63 | P08962 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.38 |
| ▸ | CASR | P41180 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.34 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.34 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.34 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.34 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.34 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.34 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.34 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27181434 | 1.00 | SYK (0.39) | SYKCD63HCRTR2CASROPRK1 | |
| SCHEMBL27180720 | 0.89 | HCRTR2 (0.35) | SYKCD63HCRTR2OPRK1HDAC6 | |
| SCHEMBL29723821 | 0.89 | HCRTR2 (0.35) | SYKCD63HCRTR2OPRK1HDAC6 | |
| SCHEMBL24529205 | 0.89 | HCRTR2 (0.35) | SYKCD63HCRTR2OPRK1HDAC6 | |
| SCHEMBL24529266 | 0.81 | HCRTR2 (0.55) | SYKCD63HCRTR2AURKA | |
| SCHEMBL27180734 | 0.81 | HCRTR2 (0.55) | SYKCD63HCRTR2AURKA | |
| SCHEMBL24529325 | 0.80 | HCRTR2 (0.54) | SYKHCRTR2HDAC6 | |
| SCHEMBL27179410 | 0.80 | HCRTR2 (0.54) | SYKHCRTR2HDAC6 | |
| SCHEMBL24529531 | 0.79 | HCRTR2 (0.52) | HCRTR2OPRK1 | |
| SCHEMBL27179772 | 0.79 | HCRTR2 (0.52) | HCRTR2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262788-B1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20240101555-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-03-28 | — | — | US | disclosed |
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240101555-A1 | UREA OREXIN RECEPTOR AGONISTS | HCRTR1, HCRTR2, UTS2R | SYK 4422/4885CD63 4726/4885HCRTR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.