Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 12/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529146 | 0.90 | HCRTR2 (0.72) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL27179807 | 0.90 | HCRTR2 (0.72) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL29723568 | 0.90 | HCRTR2 (0.72) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL24529218 | 0.86 | HCRTR2 (0.75) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL27179411 | 0.86 | HCRTR2 (0.75) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL24529465 | 0.85 | HCRTR2 (0.78) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL29723429 | 0.85 | HCRTR2 (0.78) | HCRTR2EPHB4SYKAURKA | |
| SCHEMBL29723430 | 0.85 | HCRTR2 (0.83) | HCRTR2EPHB4SYK | |
| SCHEMBL24529460 | 0.85 | HCRTR2 (0.83) | HCRTR2EPHB4SYK | |
| SCHEMBL27180108 | 0.85 | HCRTR2 (0.78) | HCRTR2EPHB4SYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |