Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 10/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529261 | 0.84 | HCRTR2 (0.44) | HCRTR2AURKASYK | |
| SCHEMBL27181187 | 0.84 | HCRTR2 (0.44) | HCRTR2AURKASYK | |
| SCHEMBL29723688 | 0.84 | HCRTR2 (0.44) | HCRTR2AURKASYK | |
| SCHEMBL24529568 | 0.78 | HCRTR2 (0.57) | HCRTR2PDE3BPDE3ANTRK1SYK | |
| SCHEMBL24529266 | 0.77 | HCRTR2 (0.55) | HCRTR2AURKASYK | |
| SCHEMBL27180734 | 0.77 | HCRTR2 (0.55) | HCRTR2AURKASYK | |
| SCHEMBL24529416 | 0.75 | HCRTR2 (0.40) | HCRTR2AURKAPDE3BPDE3ANTRK1 | |
| SCHEMBL24387026 | 0.73 | HCRTR2 (0.34) | HCRTR2PDE3BPDE3ASYK | |
| SCHEMBL29723758 | 0.73 | HCRTR2 (0.46) | HCRTR2AURKAPDE3BPDE3ASYK | |
| SCHEMBL24387028 | 0.72 | HCRTR2 (0.32) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262788-B1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20240101555-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-03-28 | — | — | US | disclosed |
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240101555-A1 | UREA OREXIN RECEPTOR AGONISTS | HCRTR1, HCRTR2, UTS2R | HCRTR2 2/4885AURKA 4623/4885PDE3B 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.