Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 8/20 | 0.42 |
| ▸ | PTGES | O14684 | 3/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29723610 | 0.85 | HCRTR2 (0.60) | HCRTR2HDAC6 | |
| SCHEMBL27179588 | 0.85 | HCRTR2 (0.60) | HCRTR2HDAC6 | |
| SCHEMBL27179589 | 0.85 | HCRTR2 (0.60) | HCRTR2HDAC6 | |
| SCHEMBL24529371 | 0.85 | HCRTR2 (0.60) | HCRTR2HDAC6 | |
| SCHEMBL29723314 | 0.82 | HCRTR2 (0.43) | HCRTR2PTGDR2 | |
| SCHEMBL24529219 | 0.82 | HCRTR2 (0.43) | HCRTR2PTGDR2 | |
| SCHEMBL27180048 | 0.82 | HCRTR2 (0.43) | HCRTR2PTGDR2 | |
| SCHEMBL24529350 | 0.81 | TLR9 (0.37) | HCRTR2EPHB4CFDPTGDR2PDE4D | |
| SCHEMBL24529283 | 0.81 | EPHB4 (0.41) | HCRTR2EPHB4 | |
| SCHEMBL24529508 | 0.77 | HCRTR2 (0.62) | HCRTR2EPHB4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |